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Abstract SUIIIIARY Phlyctenular keratoconjunctivitis is a oharacteristic nodular affection occuring mostly in children as an allergic response by the oorneal and oonjunotival epithelium to some endogenous toxins to whioh it has become sensitized. Its distribution is world-wide with a higher inoidenoe among females than male., more often in spring and sulDlller.It is most oOlDlllonlf,o.und in undern? rished ohildren who live in poor, unhygienio oonditions. The cause of phlyotenular kerato-oonjunotivitis has long been disputed, therefore many theories have been put forward in attempt to approaoh its pathogenesis. Eczema was suggested to be a oause of phlyotenulosis due to the almost constant assooiation of both oonditions hence the term eczematous kerato-oonjunotivitis. Exudative diathesis was Suggested to be another cause on account of the frequant assooiation of phlyotenulosis with scrofulous lesions which were found to be tuberculous in nature. Some observers attributed phlyctenulosis to diseased tonsils, adenoids and s1Auses and supported their view by the high inoidence of rh1Aitis, enlarged tonsils and suppurative otitis media 1A phlyotenular patients and by the improvement of the oondition after tonsillectomy and adenoidectomy. Others considered that the disease has a bacterial aetiology specially staphrlo-cocoi and streptococci which might have a significant influence on the development of a tuberculous focus and therefore on the incidenoe of phlyotenulosis. Intestinal intoxioation was considered the cause of phlyctenulosis as a result of entranoe of baoteria or their toxins into the circulation from the alimentary oanal. Parasitic infestations particularly of Hymenolepis nana worm was also suggested to be responsible for the development of phlyctens due to the state of hypersensitivity induced by the cysticercoid stage of the parasites. A faulty carbohydrate metabolism and hypovitaminosis were incrimenated as aetiologioal faotors on account that phlyctenular kerato conjunctivitis might be one of the expression of the vagus system irritability produced by some toxic agents resulting from faulty oarbohydrate metabolism. |