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Abstract Insulin like growth factor-l ( IGF-I ) is a single chain polypeptide (7.5 kilo Dalton) produced mainly in the liver through the interaction of growth hormone with growth hormone receptors in the liver (Ghahary et al., 1992) . In the circulation, it binds to a series of six specific IGF -binding proteins designated IGFBP-l to -6 (Mohan et al., 1989) IGF-l has an anabolic, endocrine and autocrine action and is regulated mainly by growth hormone and nutritional status (Ghahary et a\., 1992) Apart from its mitogenic activitv ( IGF-I ) exerts anabolic actions on proteins, carbohydrates and lipids (Underwood and vanwyk, 1992) Hypogonadism is common in both alcohol- induced and non alcohol induced liver cirrhosis manifested by small testes, low testosterone levels; decreased libido ,impotence and infertility. (Wang et al .,1991 ) Primary hypogonadism indicates that the abnormality originates III the testis; secondary hypogonadism indicates a defect at hypothalamus or pituitary glands , resulting in decreased gonadotropins (LH and / or FSH) and secondary impairment of testicular function.( Wang et al ., 1991 ) Liver cirrhosis is defined as a diffuse process characterized by fibrosis and the conversion of normal architecture into a structurally abnormal nodules ” .The pattern may be classified as either micronodular or macronodular Sherlock, 1993l. |