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Abstract r.~cu1ar degenerations can be classified into two big groups:- 1- Heredo macular degenerations: A genetically determined group of diseases which run in families include:- ;~) PrirrtJryretinal degeneI’8.tionjwhere the neuroepithelium of the retina is the seat of pe,thology with no evidence of a primary cause in the choroid. Visual affection develops at various ages according to the type of the disease. Eye affection occurs without any a asocLated degeneration of the C.N.S. such diseases are called collectively, the tapeto-Retinal Dystrophies. ~) Primary choroidal dystrouhy, where choroidal elements (choriocapillaris) together with retinal elements (neuro-and pigment epithelium) are the seat of the pathology. Sye aff~ction may occur alone as in sorsby’s pseudo- inflac)8.t’Jr~,mccuLar atrophy or with other cerebral and systemic ll13,nifestationsas lipidosis. 2- Secondary chorioretinal degenerations: Macular degeneration results from the disturbance of retinal nutrition secondary to choroidal affection. In general, the choroid is affected either by sclerosis of its vessels or by thickning of the inter capillary connective tissue. Subsequently, !ruch’s membrane and hence, the chorioretinal barrier and retinal nutrition are affected. Senile scler~sis of the choroid may result in macular degeneration, the condition is either dryas in senile macular degeneration or exudative as in senile disciform macular degenerations. Juvenile disciform macular degeneration is a similar condition to the senile type but of a different etiology and better prognosis. In degenerative axial myopia, chorioretinal atrophy results in macular degeneration and other retinal degenerations. As the macula is avascular. the persistant aedema may lead to cystoid macular degeneralian. In retinal hypoxia. lipid masses may be deposited around the macula forming a ring; this ring with macular degeneration constitutes what is called circinate macula~ degeneration. Recently, the abuse of photocoagulation is a new cause of macular degeneration. |