الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Summary
CBMZ is a frequently prescribed anticonvulsant and psychotropic
and it has many other therapeutic indications. This increasing range
of use makes it available in many homes within easy reach of
miswatched children and adults vulnerable to suicidal attempts. This
increase in incidence of intoxication by CBMZ was noticed in the
P.C.C. in the last few years.
There is controversy in literature about relation of CBMZ serum
levels and the severity of the clinical picture, so this work aimed at
correlating clinical state with CBMZ serum levels. 26 cases of acute
intoxication with CBMZ presented to the P.C.C. were studied. They
were subjected to full history, clinical examination, blood sampling
for serum Na+ and serum CBMZ level and electrocardiogram. 50%
of these cases were categorized as moderate to severe intoxication
necessitating the admission as inpatient or in intensive care units.
There was a positive correlation between CBMZ serum levels and
the grade of coma. Other findings as respiratory depression and
vomiting were seen more in the higher CBMZ serum levels. There
was a significant DROP in B.P. in the intoxicated cases with CBMZ.
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Summary
This DROP negatively correlated to CBMZ serum levels. Pulse rate
varied where sinus tachycardia was seen more in higher CBMZ
serum levels, whilst bradycardia was seen more in moderately
elevated CBMZ serum levels. E.C.G. changes were in the form of
increased P-R interval which was more in the moderately elevated
CBMZ serum levels, whilst wide QRS complex was more in the
higher CBMZ levels. Although hyponatremia has been theorized to
occur, there were no significant decrease in serum Na+ levels in our
study.
Our CBMZ intoxicated cases were classified according to line of
management and grade of severity as follows:
- Outpatient I Non toxic group (11.5%)
With CBMZ serum levels s 12 ug/ml
- Observation I Mild toxicity (38.5%)
With CBMZ serum levels between 12-23.5 ug/ml
- Inpatient I Moderate toxicity (27%)
With CBMZ serum levels between 23.5-35 ug/ml
- Intensive care unit I Severe toxicity (23%)
With CBMZ serum levels more than 35 ug/ml
All of our CBMZ intoxicated cases were fully recovered and no
deaths had occurred.