الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
SUMMARY
Congenital , hypothyroidism is one of the most common preventable
causes of mental retardation, which has an overall incidence of approximately
1 in 4000 newborns.
The diagnosis and treatment of infants with congenital hypothyroidism
has been greatly facilitated by the advent of screening programs based on filter
paper methodology.
The current trend to early discharge tends to increase the number of
. infants diagnosed as early transient hypothyroidism due to higher TSH
concentrations within the first 3 days of life.
Transient hypothyroidism represents a condition that closely resembles
mild hypothyroidism. This condition can also occuring in association with
prematurity, sepsis, respiratory distress syndrome and birth asphyxia.
This work was carried out on 69 high risk neonates,, they were classified
into 2 groups, Full-term high risk and Pre-term high risk newborns, 46 healthy
full-term newborns of matched age and sex served as control group.
All newborns were subjected to the following laboratory investigations:
(1)Assessment of C-reactive protein.
(2)Measurements of thyrotropin and free thyroxine levels in blood
in 2 steps, first-step tests after the age of 5th day of life and
second-step test at the 4th
- 6th week of age.
The results of the study revealed that:
On comparmg our high risk newborns with control newborns for TSH
and free T4 concentrations we found that:
• According to gestational age, significant mcrease m initial TSH
concentrations and a very highly significant decrease in initial free T4
concentrations in Pre-term high risk newborns were detected.
• According to birth weight, a highly significant increase in initial TSH
concentrations in LBW infants and a significant decrease in initial free T4
concentrations in LBW and VLBW high risk newborns, can be detected.
• Newborns positive for CRP showed a highly significant decrease in initial
free T4 concentrations.
• Newborns received dopamine showed a highly significant decrease in initial
free T4 concentrations.