الفهرس 
Hepatitis c virusOnly 14 pages are availabe for public view
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Abstract
The present study was done to demonstrate the prevalence
of DM among HCV infected patients. However, HCV infection
may be an additional risk factors for the development of DM
i.e. HCV may be a diabetogenic.
This study carried out on 200 HCV infected patients
randomly selected from those attending the internal medicine
department of Benha University Hospitals and 100
seronegatives for HCV as a control group.
Patients with history, clinical examination or investigation
of bilharziasis, HBV infection, alcholol consumption, renal
failure and drug administration as diuretics, interferon, α or B
sympathetic blockers were excluded from this study.
In this study the following results was found:
It was found that the prevalence of DM was significantly
increased in HCV infected patients as compared with the
control group (39% versus 12%) (Z= 5.241, P <0.01).
The prevalence of DM in HCV infected patients in this
study was found increased with the progression of the state of
liver affection with percentage of 22.9% in non cirrhotics,
35.7% in compensated cirrhotics, 48.6% in decompensated
cirrhotics and 70% in cirrhotics with HCC.
Summary
There was a significant increase in the mean age in the
HCV +ve diabetics (56.2 ± 9.7) as compared to non diabetics
(48.9 ± 11.9) (P < 0.05).
There was a non significant difference concerning to sex
between HCV +ve diabetics and non diabetics (P >0.05).
It was found that, the role of family history for developing
of DM was significantly increased in HCV-ve (controls) than
in HCV +ve patients.
There was a significant increase between diabetics and
non diabetics of HCV +ve subgroups as regarding clinical
presentations concerning to (jaundice, ascitis, right
hypochondrial pain, neurological disorders and symptoms of
DM) (P < 0.01 to all).
There was a significant increase between HCV +ve
diabetics and non diabetics as regarding liver function tests
concerning to s. bilirubin, AST, ALT, s. albumin, s. alkaline
phosphatase, prothrombin time and a significant decrease
concerning to prothrombin concentration (P < 0.01 to all).
There was a significant decrease in platelet count in HCV
+ve diabetics (109.153 ± 28.506) as compared to non
diabetics (140.437 ± 18.318) (P <0.05).
However, the high prevalence of DM among HCV
infected patients in this study may be due to: a) Direct effect
of HCV on β- cells which leads to its destruction. b) As a part
of the extrahepatic manifestations of HCV which may trigger
Summary
an auto-immuno phenomena which affects the β-cells leading
to its destruction. c) Abnormalities of glucose metabolism in
cirrhotic patients via number of varied mechanisms that
include insulin resistance, stress response related to
established cirrhosis and reduced hepatic uptake of glucose. d)
Other factor as the possibility of iron overload. However, in
this study, the highest prevalence of DM was found in those
cirrhotic patients complicated with HCC; this may be due to:
a) Long standing liver affection. b) Advanced state of liver
decompensation. c) The advanced age of these patients relatively.