الفهرس | Only 14 pages are availabe for public view |
Abstract Perfect discrimination at any early stage of pregnancy between who remain normotensive and those who later on develop pregnancy induced hypertension is a goal to maximise the safety of the mother and baby from hypertensive disorder complications. Many clinical, biophysical and biochemical tests have been recommended for predicting the development of preeclampsia. The findings of numerous studies have been inconsistent and contradictory, owing to the heterogenecity of the studied populations and variations in the definitions used for hypertensive disorders during pregnancy and in methods used to express results. In this study, the mean arterial blood pressure, the roll over, the cold pressor and the isometric exercise tests have been proposed to predict the development of pregnancy induced hypertension. from the results, it can be concluded that: Preeclampsia was associated with a high concentration of serum inhibin at 24 weeks denoting its validity as a good predictor of preeclampsia before the appearance of clinical manifestations. Tests reliant on blood pressure measurement (positive roll over, cold pressor, isometric exercise tests and elevated mean arterial blood pressure) when used individually as predictors for preeclampsia showed good predictive values. Discussion _________________________________________________________________________________________ _ 881 RECOMMENDATIONS The addition of the screening tests for the prediction of preeclampsia to the schedule of the routine antenatal care is encouraged especially for primigravidas. When roll over, cold pressor and isometric exercise tests and elevated mean arterial blood pressure are used together as tests, for prediction of the subsequent development of preeclampsia they show good sensitivity and positive predictive values. Additionally, they are easy to perform, readily interpretable, and non-invasive. Serum inhibin is a good predictor of preeclampsia before the appearance of clinical manifestations and should be done if resources allow. To obtain a univesally acceptable and reliable screening test for prediction of preeclampsia, further prospective studies are needed after establishment of strict criteria to diagnose and classify hypertension during pregnancy. In addition., only healthy nulliparous pregnant women should be included. Also for methods based on blood pressure measurements to be effective, increased uniformity of recording measurement is necessary. |