الفهرس 
Basic ocular immunologyOnly 14 pages are availabe for public view
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Abstract
Corneal graft rejection e”” be consid”r ••d as one
of the main causes of late graft failure. This 50
callea immune allograft re~ction. Fortionataly this
allogr~ft reaction takes pl~Qe in a small percentage of
gratted corneas.
The ~lIcgraft reaction OCCurs usually ~fter a
latent p~riod ranging from two ~eQks up to many year~.
Thio; tim” i s needed for the i1l1Il1unreaction to be
completed” How@ver, it may be as early as thr~@ days
after regrafting due to the previow,; sellsiti~ation of
the host to the same donor antigens. sensitization
also, occurs after blood transfusion, pre9nancies arid
other organ transplantation~”
It is suggested that tissue typing e~pecial1y in
thOSe hosts presynth.:lt.ized to the donor antigens or
with vascl.Uarised recipient beds-hi9h r.i, Sk <;ases-W’i11
,reduce much th~ rate of histo-inoornpatibility between
the donor and recipient arid in tUJ:”’n will reduce the
rate or rej~ction episoJes.
It is better to avoid t.hi G reaction b@tore it
oocurs by means of
-”]5-
1- l:Iest se.lection of the. dorio r graft m...t•~rial as
n;!’ilards the age of th~ donor, the cause - of d”’ath,
acul~r pathology i~ presant, and reducing the interval
bct”’een death 1l.J1d enucleation and transplantation AS
mUQh as possible.
,2- Good storage and preservation of the donor
rnat:e~ialor better, the usa of a ~res~ mat~rial.
3- 6iomicroscopic asseSSl1Ieht of the donor cornea
to select tha grafts with competent endoth~lia1 cell
count to be able to withstand any rejection @pi50de, if
it occurs.
4- ~reatment of the donor graft by several means
to reduc@ its ant ig~nici ty as by culture or placement
in a high titre dntidonor serum.
5- The use of prophylactic steroids of suggested
by BOIDe surgeons.
The rate of OC~Orcnce of allograft reaction can be
reduced by modification of surgical technique~ e.g the
use of smallsl: grafts and less irritant ”lI\onofil”’lI1ent
<nylon sutur~s.