الفهرس 
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Abstract
This study aimed at evaluation of the presence of ACA IgG and IgM in chronic hepatitis C infected patients. The study was carried out on 59 chronic hepatitis C infected patients and 21 healthy control. All the patients were HCV-RNA positive confirmed by PCR, HBs Ag and HIV negative. Non of our patients was receiving interferon theraphy during the study. All patients and controls were subjected to the following :
1-Full clinical evaluation : including history taking and full clinical examination .
2-Fasting blood sample was drown from each person and subjected to:
a-platelet count.
b-AST ,ALT & y GT .
c-ACA IgM & IgG.
The statistical analysis of the study showed :
1-There was a significant decrease in platelet count in chronic HCV infected patients compared with control group.
2-There was a significant increase in AST serum levels in chronic HCV infected patients compared with control group.
3-There was a significant increase in ALT serum levels in chronic HCV infected patients compared with control group.
4 -There was a significant increase in yGT serum levels in chronic HCV patients compared with control group.
5-15 of our patients were ACA/IgG positive while 44 patients were ACA IgG negative. The percentage of positivity was 25.42%. Non of the controls was ACA IgG positive. The percentage of positivity was 0%. There was a significant increase in ACA IgG serum levels in chronic HCV patients compared with control group.
6-Only lof our patients was ACA IgM positive while 58 patients was ACA IgM negative.The percentage of positivity was 1.69%. Non of the controls was ACA IgM positive. Thepercentage of positivity was 0%.There was non significant increase in ACA IgM in chronic HCV compared with control group.
7-There was non significant difference between ACA IgG positive and negative cases as regard age and ALT serum levels.
8-There was a significant increase in ACA IgG positive cases compared with ACA Igo negative cases as regard female to male ratio .
9-There was a significant decrease in platelet count in ACA IgG positive cases compared with ACA IgG negative cases.
10-The presence of thrombotic events and portal hypertension was related to the positivity of ACA IgG.
from this results we concluded that:
1- HCV infection is associated with a high prevalence of ACA.
2- ACA might be responsible for the high incidence of thrombocytopenia and thrombotic events in HCV patients.
3- HCV might be an additional recognized cause of APS.