الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
HbAlc is the major of minor components of HbA1’ It is formed inside red blood cells by a non-enzymatic condensation of HbA with glucose throughout the life span of red blood cells. The advantage of its measuring is that a single determination can substitute for several glucose determinations made at intervals as it represents an integrated record of blood glucose concentration over a period of several weeks. Since information on other factors or pathological conditions which may alter HbAl concentrations is limited, the clinical
application of this test has been confined to diabetic patients. We reported here a study on glycosylated hemoglobin in chronic renal failure (CRF) with and without diabetes mellitus (D.M.) This study was carried out on three groups of subjects
normal subjects (control).
patients with CRF.
Group 3 : 15 patients with CRF and D.M.
All the cases in ourstudywere subjected to thorough clinical
examination as well as the following laboratory investigations:
-Determination of plasma creatinine. (Pl. c.).
-Determination of fasting blood glucose (Fasting bl. gl.)
-Determination of HbAlc.
The results showed that :
(1)Fasting blood glucose level in C.R.F. patients is signif-icantly higher than that in control subjects, its is also significantly elevated in C.R.F. patients with D.M.
(2)Plasma creatinine in C.R.F. patients is significantly
higher than that in control group and C.R.F. patients. with D.M.
(3)HbAlc concentration in C.R.F. patients is significantly
higher than that in control group but still lower than that in C.R.F. patients with D.M.
Correlation studies revealed :
A significant correlation between fasting blood glucose and HbAlc in control group and patients with chronic
renal failure with diabetes mellitus, but not in C.R.F patients.
No significant correlation between plasma creatinine and fasting blood glucose in all groups.
A significant correlation between HbAlc and plasma creatinine
in CRF patients but not in control group or C.R.F with D.M.
The probable explanation of these findings were discussed.
These results gave the conculsion that HbAir can be used as an index of long-term diabetic control and it can also be used as a screen test for assessment of kidney function after exculsion of diabetes mellitus as a contributing