الفهرس 
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Abstract
This work included 45 neonates whose postnatal
ages ranged from 3-7 days. They were classified into 2
groups :
tM.. normal (n= 18), which were subdivided
into full term a d preterm babies.
The sick n nates (n=27), which vere subdivided
into septicemic, asphyxic and pneumonic neonates.
All neonates were subjected to thorough history
taking and clini al examination.
The gestati and body weight were relevant
for the normal a sick groups as well as for the
studied subgroups.
All cases we e tested as regards serum creatinine,
urea, urinary total protein and R.B.P.
excretion using u timed urine samples. Urinary proteins
w~~e expressed as rat·os to urinary creatinine to account
for variations in urine flow rate.
Serum crea inine and urea, were found to be
insignificantly i creased in the normal P.T. neonates
3 sick SUbgroups did not statistically differ from one
when compared wi h normal F.T. neonates and in the sick
group when compar d to the healthy group. Moreover, the
another nor from he healthy group as regards serum
creatinine and u
144
The normal
urinary proteins
This increase was
P/Cr
P.T. babies had higher values for
compared with normal F.T. babies.
nly significant for u RBP/Cr and u
d P < 0.001 respectively).
neonates, the measurements for
urinary proteins r corded the highest values in the
septicemic neonate followed by the asphyxic then the
pneumonia ones. iof urinary proteins were
significantly dlff rent in each of the 3 sick subgroups
when compared with the healthy group. These differences
were most slgnific nt for u R.B.P/Cr followed by u P/Cr
then u A/Cr.
When we fied the sick group into F.T. and
P.T. neonates, th increase in urinary proteins with
sickness was most oticeab1e when comparing the F.T.
sick and healthy For the P.T. infants, the
a trend with sickness but the
ranges were such hat significance was not reached.
The calculate upper limit of normal for u RBP/Cr
was 3669 ~gl mmo1 reatinlne.
In the neonates 77~8% (7/9) had u
RBP/Cr ratios abo e the upper li.it of normal, 66.7\
(6.9) in asphyxiat d neonates and the same percentage
for pneumonic neo ates.
aminoglycosides as
their therapy rec rded higher values of u
a part of
RBP/Cr when
145
compared to those treated with penicillins or
cephalosporins but no statistical significance was
observed.
The commonest organisms isolated from blood
cultures of septi emic neonates were E.coli (4
neonates), pseudomon s (2 neonates) and staph.aureu5 (1
neonate).
As a group, the sick babies had significant rise
in urinary proteins when compared with the healthy
group. This was most significant for u RBP/Cr followed
by u P/Cr then u AI r (P < 0.0001, P < 0.001 and < 0.01
respectively).
Out of the sic group 77.37\) (19/27) had u RBP/Cr
ratio above the ulated upper limit of normal. The
association between u RBP/Cr and u A/Cr ratios gave a
correlation coeffic ent of 0.46 which only accounts for
a 28% agreement bet een these 2 measurements.
The correlatio coefficient between u RBP/Cr and
~P/Cr ratios was 0.6 which only accounts for a 39%
ag~eement between t ese 2 measurements.