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Abstract This work included 45 neonates whose postnatal ages ranged from 3-7 days. They were classified into 2 groups : tM.. normal (n= 18), which were subdivided into full term a d preterm babies. The sick n nates (n=27), which vere subdivided into septicemic, asphyxic and pneumonic neonates. All neonates were subjected to thorough history taking and clini al examination. The gestati and body weight were relevant for the normal a sick groups as well as for the studied subgroups. All cases we e tested as regards serum creatinine, urea, urinary total protein and R.B.P. excretion using u timed urine samples. Urinary proteins w~~e expressed as rat·os to urinary creatinine to account for variations in urine flow rate. Serum crea inine and urea, were found to be insignificantly i creased in the normal P.T. neonates 3 sick SUbgroups did not statistically differ from one when compared wi h normal F.T. neonates and in the sick group when compar d to the healthy group. Moreover, the another nor from he healthy group as regards serum creatinine and u 144 The normal urinary proteins This increase was P/Cr P.T. babies had higher values for compared with normal F.T. babies. nly significant for u RBP/Cr and u d P < 0.001 respectively). neonates, the measurements for urinary proteins r corded the highest values in the septicemic neonate followed by the asphyxic then the pneumonia ones. iof urinary proteins were significantly dlff rent in each of the 3 sick subgroups when compared with the healthy group. These differences were most slgnific nt for u R.B.P/Cr followed by u P/Cr then u A/Cr. When we fied the sick group into F.T. and P.T. neonates, th increase in urinary proteins with sickness was most oticeab1e when comparing the F.T. sick and healthy For the P.T. infants, the a trend with sickness but the ranges were such hat significance was not reached. The calculate upper limit of normal for u RBP/Cr was 3669 ~gl mmo1 reatinlne. In the neonates 77~8% (7/9) had u RBP/Cr ratios abo e the upper li.it of normal, 66.7\ (6.9) in asphyxiat d neonates and the same percentage for pneumonic neo ates. aminoglycosides as their therapy rec rded higher values of u a part of RBP/Cr when 145 compared to those treated with penicillins or cephalosporins but no statistical significance was observed. The commonest organisms isolated from blood cultures of septi emic neonates were E.coli (4 neonates), pseudomon s (2 neonates) and staph.aureu5 (1 neonate). As a group, the sick babies had significant rise in urinary proteins when compared with the healthy group. This was most significant for u RBP/Cr followed by u P/Cr then u AI r (P < 0.0001, P < 0.001 and < 0.01 respectively). Out of the sic group 77.37\) (19/27) had u RBP/Cr ratio above the ulated upper limit of normal. The association between u RBP/Cr and u A/Cr ratios gave a correlation coeffic ent of 0.46 which only accounts for a 28% agreement bet een these 2 measurements. The correlatio coefficient between u RBP/Cr and ~P/Cr ratios was 0.6 which only accounts for a 39% ag~eement between t ese 2 measurements. |