الفهرس 
Bronchial asthmaOnly 14 pages are availabe for public view
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Abstract
Allergolc d15eases are cOlllmonproblI’JlI\s • .’!ltff!cting 12 to 2” Percent of ,cbildren lX:!eUllan. It’6). Th~ 1’-0s1: llT1portant
one is bronchia.} ~sthlll,a which a.£tects: 5 to Hl percent of
total pODulatlon and yet rllulhll under diagnosed ~nd
\Ind••rtr ••”,tlild <r1.”~lng’. 19871. The causes of the disease CAn
be clas.ified as inherited or acq~lred. Epidemiological
S’tUdUtA H’l(llc8te with one important excptlon that 1I5tbma 111
,an a.cqulred dlaease determined by. the ,env1ronll\en<t. The only
c},ear exception to this a s atopy w’hleh is a gent1cally
determined risk fi!lctor t;or asthl1lil. 111t1hou9h the preeise l1’lOde
of inheritanc: is unltnovn lHarsh. 19811. Atopy is p,resent in
;Jibout 81l” of p”,Uenh ”ith childhood asthma lNelson. 1985l.
19£ levels are ~J.v~’~d11’1 &era of most patl~n~s vith
atop1c dlsllIlS~. ’~ChIl5 allth’MIl (Vlttlq. 1985I and chHdren
”be) have e1evl’Iotfld ,erulIl l’9E levels in tbe first year of life
have II greater llkel UlOI)~ to d.velop allergic sym,ptollls 121ter
in childhood.
I9E play!! an 11lIporta.nt role In tbe pllthogenest. of
allergic asthma. It mediates its effect by binding: to mallt
cells which l1.n. the respiratory tract. Interaet.lo’i’l of
allergen vith IgE !;Iol,lnd to, lIlast cells results in the releas,e
of vasoactive llIedi!ltors and the c:),;u”aot”’:ri”,t1-c t1y”,ptoms of
asthma lee et a1., 198Bl.