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Abstract
Pathogenesis of nephrotic syndrome is still unclear. The role of nitric
oxide in the pathogenesis of nephrotic syndrome has been postulated very
recently. Changes in the generation or actions of nitric oxide contribute to
pathologic states.
The present case control study, was conducted to investigate changes in
nitric oxide synthase among nephrotic cases. The study included 24 nephrotic
cases divided into two groups ; first group included 7 patients recently
diagnosed as nephritic cases and did not start steroid therapy. The second group
included 17 nephrotic patients have just started steroid therapy. Comparison
was done between the cases and matched controls (27 normal children) on one
hand and between first and second groups on the other hand.