الفهرس 
Materials And MethodsOnly 14 pages are availabe for public view
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Abstract
Androgen therapy has been widely used in the treatment of
male infertility and impotence .
This study was done to evaluate the safety of oral
mesterolone and intramuscular injection of testosterone
enanthate when given either empirically or to hypogonadal men
on the mean values of blood indices .
This work comprised 52 patients who suffered from
impotence ( 25 patients ) and male infertility ( 27 patients)
and selected from the outpatient clinics of Benha University
Hospital and Mansoura University Hospital .
They were divided into two groups :- Mesterolone group
( comprised patients randomized to receive 75 mg daily of oral
mesterolone ) and testosterone enanthate group ( included
patients randomized to receive 250 mg monthly of intramuscular
testosterone enanthate ) .
The Mesterolone group: - comprised 30 patients with ages
varying from 24 to 44 years. Sixteen patients suffered from
erectile dysfunction and the other fourteen patients
complaining male infertility.
The Testosterone enanthate group:- include 22 patients
with ages varying from 22 to 65 years, eleven patients suffered
from erectile dysfunction and the same number of patients
complaining male infertility
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All members of the study were subjected to thorough history
talking general and local examination , measurment of
different blood indices such as: venous haematocrite ,
haemoglobin concentration , mean corpuscular volume, mean
corpuscular haemoglobin and mean corpuscular haemoglobin
concentration before 3 months after administeration of
androgen therapy . Red blood cells count, white blood cells
count are also measured before and 3 months after treatment
with androgen therapy. Also serum testosterone was measured
before and at the end of the treatment period.
There were statistically significant increase 111 the mean
values of venous haematocrite , haemoglobin concentration and
mean corpuscular volume among the two groups. Also there
were significant increase In red blood cell count, whit blood
cell count , platelets count after the treatment period among
both groups.
There were no statistically significant changes in mean
corpuscular haemoglobin mean corpuscular haemoglobin
concentration and serum testosterone levels among both groups
3 months after treatment.
According to these results we can speculate that mean
values of blood indices’ were significantly increased after
administration of oral and injectable androgens to impotent and
infertile patients hence, the danger of haemoconcentration
may develop.
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So, we recommend a careful administeration of impirical
androgen therapy for impotent and infertile patients to avoid
the complications of haemoconcentration