الفهرس 
Material and methodsOnly 14 pages are availabe for public view
 |  | from | 249 |  |  |
| | | from | 249 | | |
Abstract
The effect of B-adrenergic recptor
processes of oogenesise, maturation of
and ovulation was investigated.
blockers
Graffian
on the
follicle
The animals Used were rats due to:-
- Similarity of the mechanisms involved in oogenesis,
maturation of Graffian follicle and ovulation to man
- Ability to determine the stages of estrous cycle
accurately.
The B. adrenergic receptor blockers used were
- Propranolol hydroch!oride which is non selective and
cree. blood brain barrier.
- Nadolol ”which is non selective and doesn I t cross blood
brain barrier.
Metoprolol
adrenergic receptor
barrier.
tartrate
blocker
which is
and cross
selective B
blood brain
The Sacrification of the animals at metestrus stage
was Preferred than the Sacriflcation of them at
Proestrous ~tage.
The effect of sUbcutaneous injection of propranolol
hydrochloride (3 mg/Kg Day) for 4 weeks was insignificant
on the processes of oogenesis and ovulation.
The sUbcutaneous injection of propranolol
hydrochloride in a dose of (5 mg/kg/Day) for 8 weeks
caused significant reduction in the number of growing
Graffian follicles and corpora~ lutea and this effect was
reversible.
The sUbcutaneous injection of equipotent dose of
nadolol (5.5 mg/Kg/D) for 8 weeks caused significant
reduction in the number of growing Graffian follicles and
Ijorpora lutf!a,
The sUbcutaneous injection of equipotent dose of
metoprolol tartrate (7.5 mg/Kg / Day) for 8 weeks caused
insignificant effect in the number of growing Graffian
follicle and corpora lutea.
As the number of growing Graffian follicle represent
a parameter for the process of oogenesis and maturation
of Graffian fallicle and the number of corpora lutea
represent a parameter for ovulation, thus propranolol and
nadolol (in the doses used) decreased the process of
oogenesls, maturation of Graffian falllcle and ovulation
,1
while metoprolol has no significant effect
Induction of ovulation by P.M.S. gonadotrophin
caused the same histological change (excessive
luteinization and absence of growing Graffian follicles
in control, Propranolol and nadolol treated group. The
above finding denotes that the inhibitory effect of
nadolol and Propranolol on the process of Graffian
follicle maturation and ovulation may be due to decrease
in F.S.H. and L.H.