الفهرس 
Uses diethanolamineOnly 14 pages are availabe for public view
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Abstract
Diethanolamine (DEA) is a secondary amine in which two molecules of ethanol are linked through their beta carbon to a common nitrogen. It is widely used in soaps, cosmetics, shampoos and hair conditioners. It is also used as an ingredient in pharmaceutical products as drugs administered intravenously or intramuscularly and skin creams. In addition DEA is used in the preparation of agricultural chemicals and as intermediate in rubber, textile and metal industries. The aim of this experimental study was to asses the toxic effects of diethanolamine. The present study was conducted on 160 adult male albino rats evaluate the toxic effects of DEA by the dermal and oral routes for two different dose response and time course intervals. In the dermal study, rats exposed to 0. 500, 1000 and 2000 mg/kg DEA once daily for 2 weeks and 125, 250 and 500 mg/kg for 13 weeks. DEA in ethanol 95% was applied on 2 cm2 area of shaved mid back rat skin . in the oral study rats received 0, 2500, 5000& 1000 ppm / kg DEA once daily for 2 weeks and 0, 1250, 2500 & 5000 ppm/ kg DEA once daily orally for 13 weeks DEA in the oral study were given diluted in distilled water. All rats were subjected to clinical observation, body and organ weighing, hematological, biochemical, semen analysis and histopathological examination. The clinical signs observed on treated rats were hypoactivity, emaciation and convulsions. There was irritation and crustation of the skin at the site of application in the dermal exposure. Hair growth arrest was observed in rats exposed to 500 mg/ kg dermally for 13 weeks. The mortality rate of some groups ranged from 10% to 40 % especially in high doses. The final body weights of all DEA treated groups were significantly decreased except with the lowest dose in the dermal and oral exposure for 13 weeks. The lung, heart and kidney ( absolute and relative ) weights.