الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
a The effects of two different diuretics, furosemide and mersalyl on the biological half-life (t) and the apparent voluuleof distribution (Vd) of amoxicillin and ampicillin were studied. The antibiotics WBPe assayed by agar diffusion method using Bacillus subtilis as test organism. A linear”relation ,ship has been found between Log conc. and inhibition zone in concetration ranging from 0.78 to 50 ug/ml of both antibiotics. The control rabbit. received i.m. dose of 100 mg/kg of either antibiotic alone. The experr.1intal groups were administ ered either i.m. injection of 100 rng/kg of a,doxicillin with 2 mg/kg furosemide or i.m. injection of 100’mg/kg ampicillin with o.~ ml/kg mersalyl. Three or four blood samples were taken from each animal and assayed. 1) The result obtained in this investigation indicate that: Furosemide has an apparent increase in the tof arnoxicillin but this was statistically insignificant. 2) Furosemide has statistically insignificant increase ift.the Vd of amoxicillin. r ) r Rabbits administered with furosemide and amoxicillin simultaneously showed a decrease in the serum levels of 4) amoxicillin during the first two hours. Mersalyl has no statistically significant effect on the t}2 or Vd of ampicillin, although it had an apparent decrease in the Vd of ampicillin. 5) Rabbits administered with” mersalyl and ampicillin showed elevated serum levels of ampicillin than the control group during the first two hours.