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Abstract In this study a review of epidemiology, pathology, and diagnosis of bilharziasis was done. Also a review of viral hepatitis and chronic hepatitis was studied. In addi tion there was chapter in viral hepatitis with bilharziasis. In the practical study 72 inpatients in endemic disease section in Ain Shams University were selected. All of them were proved to be bilharzial by one or more of the diagnostic methods. Their stools were examined by the three quantitative stool examination techniques, Kato, Bell and Ritche. In addition they were examined by rectal snip transparency technique. Out of them 48 patients were examined by concentrated Bell technique (it is a modification of Bell technique induced by us). 130 patients were inquired about their symptoms and examined clinically. Their stools were examined for Schistosoma mansoni eggs by Kato technique. They are -262- classified into four group according to intensity of infection: 1- Negative stool cases (negative egg). 2- Light intensity of infection (10-100 egg~grm). 3- Moderate intensity of infection (101-400 ego//grm) 4- Heavy intensity of infection (more than 400 eggs/ gram) . The frequency of the signs and symptoms of the disease were studied in each group to detect the correlation between the intensity of infection and the clinical picture of the patient. Ten patients with active S.mansoni infection were examined by Kato technique for several successive days. All of them were positive for S.mansoni eggs. The daily deviation of egg counts recovered by Kato technique was studied. The stool of two patients with heavy intensity of -------- -263- intestinal infection were examined by Kato technique. From each premixed motion of the same pati.nt we prepare five slides for examination by Kato technique to detect the deviation of egg counts from slide to slide from the same motion of the same patient. 30 mice were infected with ~imansoni cercaria. Ten mice were Eacrified after 1.5 month, ~ months and 3 months respectivly. The stool of each mous~ at the last living day was examined by Kato technique fot S.mansoni ova. The Schistosoma worms were counted. The correlation between the worm burden and the egg counts were studied. The stools of eight mice wer~ examined for sex successive days by Kato technique for S.mansoni eggs, to study the deviation of egg counts fron day to day. 127 inpatients with bilharziasis or past history of antibilharzial treatment were chosen . Each patient -264-- was examined clinically, the stool was examined for S.mansoni eggs by Kato technique and liver biopsy was taken. According to liver biopsy examinations we classified the total bilharzial patients into: 1- Patients with pure bilharzial liver (52) 2- Patients with chronic persistent hepatitis(C.P.H) (22 ). 3- Patients with C.P.H with bilharziasis (20). 4- Patients with chronic active hepatitis (C.A.H.) (23) 5- Patients with C.A.H with bilharziasis (10) The frquency of patients with positive S.mansoni eggs in stool in each group was studied. The correlation between the intensity of excreted S.mansoni eggs in stool and each of the histopathological -265-. group was studied. Correlation between the intensity of excreted S.mansoni egg and size of liver or spleen in patients with pure bilharzial liver, C.P.H and C.A.H were done respectivly |