الفهرس Only 14 pages are availabe for public view
 |  | from | 152 |  |  |
| | | from | 152 | | |
Abstract
Introduction:The differentiation inhibitory factor [NM23] can inhibit the differentiation of murine and human myeloid
leukemia cells, [NM23] genes play a role in the growth and differentiation of normal and malignant hematopoietic
cells. a statistically significant correlation between the expression of [NM23-H1] was observed in ALL , a poor
prognosis and a low percentage of complete remission were also associated with the [NM23-H1] expression level.
Materials and methods: a peripheral blood sample from 25 newly diagnosed ALL cases and 10 control group
were analysed for NM23-H1 mRNA expression level by real time PCR. Results: Nm23-H1 mRNA was
overexpressed in ALL cases than for the control group with a mean level of 0.99 ± 0.74 ,0.305 ± 0299
respectively, The resistant cases expressed a significantly higher NM23-H1 level (mean = 0.975) than those
who achieved remission (mean=0.805). and dead cases expressed a highly significant level of the studied
gene (mean = 1.780). Conclusion: In our study there was highly significant positive correlation between the
level of expression of NM23-H1 gene and the outcome of the patients P value 0.001.