الفهرس Only 14 pages are availabe for public view
 |  | from | 144 |  |  |
| | | from | 144 | | |
Abstract
Hypotensive anesthesia offers a dry surgical field and may reduce blood loss and hence the need for transfusion. The influence of hypotensive anesthesia on splanchnic perfusion is ground for research. With the acknowledgment that almost all anesthetic techniques reduce liver blood flow, it would seem wise that during procedures performed under hypotensive anesthesia, where further reduction of liver blood flow may be detrimental, that the techniques and the agents used should be those that have the least effect on liver blood flow, and on hepatocellular integrity.
The aim of this work is to assess hepatocellular integrity during hypotensive anesthesia, using more specific and sensitive markers [ and ] GST and hyaluronate, comparing sevoflurane and propofol, both with relatively less predictable hepatic insult, in an attempt to find out the best anesthetic agent and technique and recommend it during such procedures.
We conclude that sevoflurane anaesthesia is associated with a transient increase in plasma GST concentrations reflecting a minor degree of impaired hepatocellular integrity especially during hypotensive anaesthesia.