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Abstract
The aim of this thesis was to study the inclusion complex formation of loratadine with a natural cyclodextrin [β-CD] and hydroxyalklated-β-cyclodextrin [HP-β-CD] in aqueous solution and in the solid state in an attempt to improve the solubility of loratadine [Ld]. The prepared complexs were evaluated by different techniques. Furthermore, the dissolution characteristics of the prepared complexs, either as a powder or after incorporation into tablets, were studied and compared with loratadine alone and the commercial tablets.morever, parenteral dosage form containing drug-cyclodextrin complex was prepared and evaluated in a subchronic study for safety.