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Abstract The present work was diabetes’ mellitus on the jt the pitui~8ry gland of the a jection of streptozotocin oneel LrisulTn. wa sed to trea ie an rats were used in this ,study.. ,The animals were 3 groups: group I (control), group II (d i abeti c an i mel and group III (diabe”ti’cpnirnals t r e e t e d with insulin). The dura- Oil 0 ~he e xper i rne n! wa s divided into 3 periods: 15 days, (JIlE’ ruor: The bpecimen~ were prared for l Igh tend electron mi cr os ccp Different histological and h i st oc h ce stains were used to examine the structQre of It was found that, the stroma and the p erenc hyfne of the pars distalis were affected by the diabetes. especially the reticular fibers. These fibers were distributed,allover the glard nnd aro~nd the blood .These events were progressed along the periods CJf the experiment (15 days, one month and two months). Dilatation in the blood capillaries was noticed. This eli 1a.”:.at iUT, is i ncrees.ed with the edvencement. of the ex- The parenchyma sh9WS ’changes in all the cells, of the pars dislb~is. The somaloLrophs are increabecl in number and. show sLve de ge’uerat month ond two mont other types; gonedo t r-ophs , trophs. The cells stainl:’ The Tiuclei and eccen deep with the electron microscope, cumulation of their their rough endopld~mic reticulum. ’These changes progred gr Thi all the sedretory grhnules appe of the experiment. Lys o some s and myelin figures were observed in some cells, In ,the lote ,Btoge of diabetes. Insulin treatment of d i ebeti animals leads to the gradual Lrr.p r overnent ill the event seres ul t ed from diabetes. The anima:s restored their general health. The cells return nearly tc their normal structure, shape, size. secretory’ granules and nuclei. The el ec t r-onvmi cr-osc’ope shows that, the, r et ur r. of t hese cellos is r.ot exec t l y similar to’ the ’normal. .Lns p ; te the long treatment with ins ul In. the reticular fiber~ ani: the dilated blood cap Lll e r i es do n’ot return t( their nOrmal appearance. Fro~ the resulls obtained ,in this stody one that. |