الفهرس Only 14 pages are availabe for public view
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Abstract
Psoriasis is an ancient and universal inflammatory disease characterized by thick scaling red plaques which can be either localized or widespread. It affects approximately 2-3% of the population worldwide. Its etiology and pathogenesis result from a combination of genetic and environmental factors. It is frequently inherited and passed from one generation to the next, but not following a classical autosomal Mendelian profile. The disease is sometimes triggered by obvious causes as trauma, drugs or bacterial superantigens. It can be both physically and emotionally debilitating. Disability and impact on life quality due to psoriasis parallels that of heart disease and arthritis.
Psoriasis is a chronic papulosquamous skin disease characterized by marked keratinocyte hyperproliferation, dense inflammatory infiltrate consisting of T cells and neutrophils, vascular dilatation and proliferation. The primary defect in psoriasis patients was believed to be abnormal epidermal cells proliferation.
Recent progress in the understanding of psoriasis has attributed its pathogenesis to the important role of T cells. At present, research into psoriasis is dominated by the hypothesis that it is an immunological disorder described by abnormal keratinocyte proliferation mediated through T lymphocytes.