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Abstract
Toxicogenomics is described as a discipline combining expertise in
toxicology, genetics, molecular biology, and environmental health to
elucidate the response of living organisms to stressful environments.
As this emerging field rapidly develops, it is important to assess how
toxicogenomic data can be applied to improve risk assessment and provide a means for personalization of medicine.
Toxicogenomics encompasses technologies that enable scientists to measure geneticsequence variation (genomics), gene transcription (transcriptomics)
protein expression (proteomics), and metabolite profiles (metabolomics)
in response to chemicals and other stressors.
These ”omics” technologies
provide an enormous amount of information that need to be interpreted
using bioinformatics tools to better prioritize data and understand a
chemical’s progression from the environment to the target tissue within
an organism and ultimately to the key steps that trigger an adverse health
effect.
Toxicogenetics deals with the person himself, it promises to
provide the specific polymorphisms responsible for the abnormal reaction
of some individuals to certain chemicals.
In the near future, through the combined efforts of both toxicogenomics and toxicogenetics, there will
be a great breakthrough in the field of medicine, providing a personalized
medicine with the best effect and the least side-effect.