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Abstract
Iatrogenic blood dyscriasias are of wide variety. It is a major challenge for clinicians to identify the drug-induced causes of these dyscriasias, and to always cosinder any concomitant drugs in the differential diagnosis of acquired hematologic dysfunctions.
The most severe drug-induced effects is bone marrow depression and aplastic anemia. Such dyscariasias are regularly caused by cytotoxic chemotherapies. Drugs that are associated commonly with bone marrow aplasia include chloramphenicol, gold, non steroidal anti-inflammatory drugs (e.g., phenylbutazone and indomethacin), and sulfonamides.
Methotrexate related hematologic toxicity may include megaloblastic anemia and pancytopenia. Also, triamterene, zidovudine, hydroxyurea, nitrous oxide, and omeprazole induce megaloblastic anemia by interfering with DNA metabolism.