الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
The major objective of the present work was to demonstrate the possible protective potential of diphenyl dimethyl bicarboxylate (DDB) against ketoconazole toxicity in two different biological conditions, namely normal feeding and protein malnutrition.
The work was conducted using male Sprague-Dawely rats. Animals were classified into two major sets, one received normal feeding diet (containing 20% casein) and the other one received protein deficient diet (containing 5% casein). Each major set was subdivided into 4 groups (received vehicle, ketoconazole, DDB and combination of DDB and ketoconazole treatment).
Ketoconazole was administrated in an oral dose of 30 mg/kg, b. wt. daily for 14 consecutive days, while DDB was given in a dose of 100 mg/kg, b. wt. two hours before ketoconazole dosage along 14 successive days using oral gavage.
The estimated parameters were biochemical indicators (ALP, ALT, T. bilirubin, T. protein and Albumin), hematological parameters (total and differential leukocytes count) and assessment of the bone marrow lymphocytes count and their percent of viability. In addition, the total body weight change and the relative weights of the liver, spleen and thymus were recorded. The histological examination of the liver, spleen and thymus was performed.
The obtained results showed that DDB has a potential to protect against ketoconazole induced insults either in normally fed or protein malnourished rats. Moreover, DDB showed a good ability to modulate biological incidences caused by protein malnutrition alone.
The protective potential of DDB is probably due to its antioxidant ability as well as its ability to induce protein synthesis.