الفهرس | Only 14 pages are availabe for public view |
Abstract The pathophysiological mechanism of acute myocardial infarction (AMI) is the rupture of an atherosclerotic plaque in an epicardial coronary artery, exposing subendothelial tissue to a subsequent thrombogenic response and leading to a complete obstruction of the vessel. Strategies directed toward achieving early and sustained reperfusion of the infarct-related artery have reduced mortality. Because glucose uptake is promoted by insulin, infusions of glucose and insulin with potassium (GIK) were initially evaluated in AMI by Sodi Pallares in 1962. However the potential role of this intervention is still uncertain. Aim of the work: To evaluate the impact of glucose insulin potassium solution during the first hours of acute anterior myocardial infarction with ST segment elevation and its effect on hospital morbidity and mortality This study is a case control analytic study that was conducted in the National Heart Institute(2006-2008) in order to find out the role of glucose Insulin infusion in diabetic patients with acute anterior wall myocardial infarction. Our study included 50 patients admitted to coronary car unit suffering from acute ST segment elevation anterior myocardial infarction. Inclusion criteria: Diabetic Patients with acute anterior myocardial infarction with ST segment elevation within 24 hours of symptom onset were eligible regardless of age. |