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Abstract
The liver is an important organ which performs complex functions including metabolism, synthesis and detoxification. As a central metabolic organ the liver regulates the body’s energy supply, secretes a diverse group of essential compounds and detoxifies the toxic waste by inactivation, recycling and excre¬tion.
Fulminant hepatic failure (FHF) is a multi-factorial process leading to instability and derangement of essential functions such as acid base balance, energy supply and thermoregulation. If not rapidly reversed, complications will lead to hepatic coma by affecting the brain and kidneys. With additional organ failure, recovery becomes irreversible and leads to a high patient mortality. The catastrophic failure of a previous normal liver is one of the most challenging emergencies in clinical medicine.