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Abstract Failed reperfusion after thrombolytic therapy for acute myocardial infarction is common and signifies a poor prognosis. Failed thrombolysis was defined as <50% ST- segment resolution 180 minutes after the start of the thrombolytic therapy. ST- segment resolution is a useful marker of successful thrombolysis and relates to clinical outcome . If assessed routinely it might assist, along with other clinical markers, in the identification of low-risk patients who can be discharged early”1”. Thrombolytic therapy for acute myocardial infarction reduce case fatality and improves clinical outcomes”2,3”,however in up to 60% of patients the treatment does not restore perfusion in the myocardium at risk ”4” and such failure indicates a worse prognosis ” 5”. In the past, reperfusion was commonly assessed in terms of coronary blood flow, achievement of TIMI 3 flow being a favourable sign; ”6” however , this angiographic index is not a reliable indicator of myocardial reperfusion which is prognostically more relevant than coronary reperfusion”7,8”. By contrast ,ST-segment resolution 90-180 minutes after thrombolysis is an excellent marker of successful myocardial reperfusion ”9” and a strong predictor of survival and preservation of left ventricular function ”10,11” |