الفهرس 
HYPERTENSIONOnly 14 pages are availabe for public view
 |  | from | 147 |  |  |
| | | from | 147 | | |
Abstract
Insulin resistance and consequent hyperinsulinemia was linked to various components of insulin resistance syndrome (IRS). Hyperinsulinemia was considered as an important metabolic variable in the pathogenesis of hypertension. Myocyte hypertrophy leading to cardiac growth was identified as a major cardiovascular risk factor in humans and characteristically, is secondary to hypertension. Cardiac hypertrophy may precede the development of essential hypertension . A role for insulin resistance with the attendant hyperinsulinemia and/or hyperglycemia in the genesis of cardiac hypertrophy has was reported on the basis of several observations. The purpose of this study is to investigate the impact of insulin resistance and hyperinsulinemia on left ventricular mass in patients with isolated systolic hypertension. The study included 60 patients with isolated systolic hypertension, 30 of them have DM type Π, the other 30 are non diabetic, and 15 healthy normal subjects (control group). Physical examination and blood pressure measurement were done to all subjects, also, 2D guided M-mode measurement of left ventricular end diastolic dimension, interventricular septum thickness, and posterior wall thickness was obtained along the LV short axis, and were used to calculate LVM and LVMI using Devereux formula.