الفهرس 
introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Atherosclerosis is a leading causes of mortality in many areas of the world. The disease has mainly been studied with respect to the pathogenic role of lipids. Hypertension is another common disease affecting the cardiovascular system. As a consequance of persistantly raised blood pressure, left venticular hypertrophy (LVH) as a compansatory mechanism. Over the last few years, recent advances in moleculsar biology have opened new avenues of researches for understanding the mechanisms and pathogenesis of atherosclerosis and hypertension. The study was performed on 16 patients with essential hypertension complicated with left ventricular hypertrophy assessed by echo-cardiographic study through measuring left ventrecular mass and 19 patients with coronary heart disease in whome coronary angiography is indicated and 15 age matched controls. All the patients included in the study were subjected to full history taking and full clinical examination, conventional laboratory investigation. Echo cardiographic study was performed including the measurement of left ventricular mass. Coronary angiography was carried out in patients with coronary atherosclerotic heart disease, Serum ras on coprotein levels and serum lipogram were measured in all subjects studied. The main aim of our study is tyo evaluate expression of ras-proto-oncogene in patients wioth essential hypertension complicated with left ventricular hypertrophy and in patients with atherosclertic heart disease. The study revealed that, there is significant elevation of ras-oncoprotein in both hypertensive and coronary atherosclerotic heart disease patients as compared with controls (p 0.001 for each)> Patients with essential hypertension showed higher ras-oncogene expression than those with coronary atherosclerotic heart disease.