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Abstract
Traditionally, recurrent miscarriage was defined as three or more consecutive pregnancy losses. Later, many clinicians begin diagnostic evaluation for the couples after two miscarriages.
Miscarriage is the most common complication of pregnancy occurring in 10 to 15% of pregnant women. Accurate figures on prevalence are not available but it has been estimated that 2 to 5% of women have 3 or more miscarriages.
There have been numerous proposed causes of recurrent miscarriage: parental chromosomal abnormalities, uterine anatomic anomalies, endometrial infection, endocrine etiologies (luteal phase defect, thyroid dysfunction, and uncontrolled diabetes mellitus), antiphospholipid syndrome, inherited thrombo-philias, and alloimmune causes.