الفهرس Only 14 pages are availabe for public view
 |  | from | 297 |  |  |
| | | from | 297 | | |
Abstract
Breast cancer is the most common cancer and the most common cause of cancer death in women. In Egypt it accounts for 27.3% of all females cancer . (Omar S. and Contesso G.,2001)
Over the last few decades a greater proportion of women are diagnosed in early stages of the disease, for which curative approaches are still possible. Nevertheless, 20–85% of these patients, depending on the initial stage, tumor biology and treatment strategy used, will develop distant metastases within 5 years of their initial diagnosis. (Cordoso F. et al., 2002)
An additional 6–10% present with metastatic disease at diagnosis . (Miller K. and Sledge G.,1999)
Once metastases are detected, the median survival is in the range of 18–24 months. (Stockler M. et al.,1999).
The Choice of treatment for metastatic breast cancer (MBC) is influenced by a wide range of factors related to patient and tumor characteristics such as:
Patient age.
Performance status.
Previous therapy.
Extent and location of metastases