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Abstract
To determine whether polymorphism in RAD51 and XRCC3 repair genes have an effect on the incidence of AML.
Methods:
PCR-RFLP was used to determine the frequency of the two genes polymorphisms among 40 cases and 20 controls.
Results:
In our study we investigated 40 cases of AML and 20 controls for the polymorphism in 2 DNA homologous recombination repair genes – RAD51 and XRCC3. We found that - regarding RAD51 gene polymorphism - among the cases there were 32 cases with positive expression of the polymorphic gene and only 8 cases with negative expression. While in controls we found only one candidate with positive expression of the same polymorphism. Regarding XRCC3 gene polymorphism; we found that among the cases there were18 cases with positive expression of the polymorphic gene and 22 cases with negative expression of this polymorphism. And among the controls there were 8 candidates with positive expression of the polymorphic gene and 12 candidates with negative expression of the polymorphic gene.
Conclusion:
Our results suggest a strong correlation between the presence of polymorphic RAD51-G135C allele and the incidence of AML.
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