الفهرس 
AnatomyOnly 14 pages are availabe for public view
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Abstract
Prostatic carcinoma is now considered the most important prostatic disease in male urological studies. The incidence of-prostatic
carcinoma has shown sharp increase over the last few years.
But unforkrnately the majority of prostatic cancer have spread beyond the gland when first diagnosed using the conventional detection
method.
Diagnosis of cancer prostate rests on two major parameters. The first is clinical and non laboratory methods, such as DRE, TRUS and biopsy guided by ultrasound. The second methods are laboratory methods such as acid phosphatase, PAP, and PSA.
PSA is a valuable tumour marker for early diagnosis and management of prostate cancer. PSA is present in normal, BPH, CAP
aid in metastatic prostatic carcinoma.
The serum PSA is present in two molecular forms, as free PSA and as PSA complex bound to proteinase inhibitors, predominantly aj
antichyrnotrypsm (ACT)., and macroglobulin (2M).
To improve the sensitivity and specificity of total PSA for early ietection of cancer prostate and discriminating it from BPH they try to
we the clinical utility of serum PSA measurements by using
concepts such as PSA density, PSA velocity and free to total
ratio.