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Abstract
This study was carried out to throw more light on the histological and Immunohistochemical of lead acetate on the development of testis of male albino rats and role of zinc supplementation.
This study was performed on forty pregnant albino rats, ten being the control group and Shaiii control group, while thirty constituted the experimental group as following:
- Subgroup A:
This consists of 15 pregnant albino rats and received lead acetate at a dose 50 mg 1kg body weight orally once daily during gestational period and through lactation.
Subgroup 13:
This consists of 15 pregnant albino rats and received lead acetate at a dose 50 mg 1kg body weight orally once daily with additional once daily dose of zinc sulfate orally one mg 1kg body weight during gestational period and through lactation.
Male offspring of the previous groups were killed by decapitation at one day, one week, two weeks, three weeks and six weeks postnatal, the abdonieii of each animal was opened by a scissor and testis were extracted and were immediately fixed in 10% in formal saline and processed to Parauim section to be stained histologically by haeinatoxylin and eosin and methyl gucen-pyronine, Immunoinstocheinically by Fas ligand antibody inununostaining.
Oral administration of lead acetate to the experiiiieiital aiiiiiials in a dose of 50 nig 1 Kg / day body weight during gestational period and through lactation revealed by light microscopic examination of testis of male offspring aged one day old.