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Abstract
Hepatocellular carcinoma is a neoplasm with a high degree of malignancy. HCC is the fifth commonest cause of cancer worldwide. Important risk factors which can lead to 11CC include HBV, IICV, aflatoxin exposure and alcohol consumption. IIBV can lead to 11CC through hepatitis B virus X Ag, while HCV can lead to HCC through the core gene. 11CC is in most cases one of the sequel of chronic hepatitis or cirrhosis, although it may occur without a proceeding known cause. Early detection of HCC can lead to good prognosis with treatment.
There is a growing body of evidence to indicate that the insulin- like growth factors play an important role in cancer risk. IGFII is a polypeptide involved in the proliferation and differentiation of normal, transformed and malignant hepatocytes. Increased expression of IGFI I at both the mRNA and protein levels has been demonstrated in HCC tissues. it is anticipated that 11CC may produce 1GFII, and serum IGF1I level may increase in patients with 11CC.
The present study was carried out on 60 patients, their age ranging from (35-73 yeats), 50 patients (seropositive to HCV) and 10 normal contrnl.
Aim., of the work is to study the relationship between serum level of insulin-like growth factor 11 in chronic hepatitis C infection and hepatocellular carcinoma.
Patients were classified into three groups:
Group 1: included 30 patients with chronic hepatitis with or without cirrhosis. This group was classified —according to Child-Pugh score- into 3 subgroups; Child A (n=l0),_child B (n=zlO), Child C (n=l0).