الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
This study comprised 100 type 2 (NIDDM), diabetic patients (age from 37 to 59yr), 56 were male and 44 were female, chosen from those attending the outpatients clinic of Menoufiya University Hospital and 20 healthy control, (age from 35 to 50yr), 13 were male and 7 were female. Each of them was investigated as follows: History taking, through clinical examination and laboratory work up which included, diabetic state assessment (Fasting & 2hr Post Prandial glucose, HbA1C, insulin, C-peptide concentrate) and assessment of liver function tests (AST,AL T, serum bilirubin, albumin, Prothrombin activity) and, Anti HCV, HBsAg, abdominal ultrasonic, •IHA for shistosomiasis to exclude shistosomal cases, liver biopsy was done for 12 cases. The aim of this study is to assess prevalence and pathogenesis of hepatic disease in type 2 DM. This study showed that in type 2 diabetic patients healthy liver was present in 200/0, fatty liver in 400/0, chronic hepatitis was found in 300/0 (positive anti HCV in 280/0, positive HBsAg in 20/0), cirrhosis in 100%Serum insulin was significantly increased in type 2 diabetic patients with liver disease in comparison to either healthy controls or those type 2 diabetic patients without liver disease. This increase was higher with the development of more advanced liver disease (highest in cirrhosis, lesser in chronic hepatitis and least in fatty liver). This reflects the association of hyperinsulinaemia and insulin resistance with advancement of liver disease.