الفهرس 
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Abstract
The major form of circulating IGF is the GH-dependent 150 kDa
complex. The liver appears to be the main source of the three components
of the 150 kDa complex and, in particular, hepatocytes synthesize the
insulin-like growth factor (IGF) peptide and the acid-labile subunit (ALS),
whereas Kupffer and sinusoidal endothelial cells produce IGF-binding
protein-3 (IGFBP-3)
Patients with liver cirrhosis exhibit reduced levels of circulating
insulin like growth factor I and its main binding protein (ILGFBP3). This
defect is thought to be caused by decreased hepatic synthesis
The aim of this study was to evaluate the usefulness of
measurment of serum ILGFBP3 in patients with compensated and
decompensated liver cirrhosis and the possible relationship of the
change between the level of serum ILGFBP3 and the routine liver
function tests.
Fifty eight patients with liver cirrhosis of different etiologies
were included in this study, they were selected from the Internal
Medicine Department-Minoufiya University Hospital during the
period from March to June 2004. Final diagnosis was established after
complete physical, laboratory and ultrasonic examination. Patients
with either haematemsis, coma, diabetes mellitus, renal failure or
hypoglycemia were excluded.