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Abstract With the use of 3D MR Spectroscopic imaging, significantly higher choline levels and significantly lower citrate levels were observed in regions of cancer compared with areas of benign prostatic hypertrophy and normal prostatic tissue. (Scheenen et al., 2005(. The ratio of these metabolites (choline to citrate) in regions of cancer appears not to overlap with rations in the normal peripheral zone, Which suggests that 3D MR spectroscopic imaging combined with MRI may improve tumor detection and localization compared to those with MRI alone (Dhingsa , et al., 2004, Bloch, et al., 2004, Scheenen, et al., 2005). |