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العنوان
Effect Of Triclabendazole On Carbohydrate and Lipid Metablism In rabbits =
الناشر
Aly Mahmoud Aly Sherif ,
المؤلف
Sherif, Aly Mahmoud Aly
هيئة الاعداد
مشرف / نبيل محمد طه
مشرف / أمال على راضى
مناقش / عبد الصادق أبو العطا يوسف
مناقش / سامى أحمد عبد العزيز
باحث / على محمود على شريف
الموضوع
Chemistry
تاريخ النشر
1999 .
عدد الصفحات
118 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
البيطري
الناشر
Aly Mahmoud Aly Sherif ,
تاريخ الإجازة
28/09/1999
مكان الإجازة
جامعة الاسكندريه - كلية الطب البيطرى - الكيمياء الحيوية
الفهرس
Only 14 pages are availabe for public view

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Abstract

The effect of anthelmintic drug triclabendazole on carbohydrate and lipid metabolism in rabbits, as well as on some hepatic function parameters was studied.
4
Sixty clinically healthy rabbits were used in this study. The animals were divided into three groups, twenty rabbits for each. First group served as control, the second group received once orally therapeutic dose (18.2 mg/kg b.wt.). The third group administered once orally double therapeutic dose (36.4 mg/kg b.wt.).
After one week post drug admirnstration, ten rabbits from each group were slaughtered, blood and liver samples were collected for biochemical analysis and hepatic glycogen content. The serum was separated for determination of blood glucose, LDH activity, serum total lipids, triacylglycerol (TAG), total cholesterol, HDL-C, VLDL-C and LDL-C, as well as serum total protein and its fractions, S.AST, S.ALT and bilirubin concentration.
The study found the following results:
1. Blood glucose:
Triclabendazole had a significant lowering effect on serum glucose, after one week post drug administration. The blood glucose returned to its normal level after two weeks post treatment till the end of the experiment.