الفهرس | Only 14 pages are availabe for public view |
Abstract The effect of anthelmintic drug triclabendazole on carbohydrate and lipid metabolism in rabbits, as well as on some hepatic function parameters was studied. 4 Sixty clinically healthy rabbits were used in this study. The animals were divided into three groups, twenty rabbits for each. First group served as control, the second group received once orally therapeutic dose (18.2 mg/kg b.wt.). The third group administered once orally double therapeutic dose (36.4 mg/kg b.wt.). After one week post drug admirnstration, ten rabbits from each group were slaughtered, blood and liver samples were collected for biochemical analysis and hepatic glycogen content. The serum was separated for determination of blood glucose, LDH activity, serum total lipids, triacylglycerol (TAG), total cholesterol, HDL-C, VLDL-C and LDL-C, as well as serum total protein and its fractions, S.AST, S.ALT and bilirubin concentration. The study found the following results: 1. Blood glucose: Triclabendazole had a significant lowering effect on serum glucose, after one week post drug administration. The blood glucose returned to its normal level after two weeks post treatment till the end of the experiment. |