الفهرس 
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Abstract
The thesis is divided into 7 parts:-
Part 1 (review of literature) contains the biochemistry of inflammation process, type of cyclooxygenase (COX) enzymes, different types of NSAIDs and other examples from the recent literature illustrating new structure modification of the existing drugs. In addition illustration of nitric oxide and hydrogen sulfide releasing anti-inflammatory agents.
Part 2 (research objectives) includes the major aims that direct the theoretical and practical work.
Part 3 contains the Results and Discussion. It explains the different possible conditions for the preparation of the desired compounds with a summarized data about the confirmation of the structures of these new compounds.
Part 4 represents the experimental part that discusses the different methods and conditions used in this thesis for the synthesis of the intermediates and the final products. The structures of the newly synthesized compounds were confirmed by the microanalyses and spectral data including IR, 1H NMR, 13C NMR and mass spectroscopy.
Part 5 represents the biological screening section which gives an idea about the anti-inflammatory, analgesic and ulcerogenic potentials of the compounds under investigation.
Part 6 includes molecular modeling study of the most active compounds.
Part 7 includes the list of 150 references and periodical literatures used in this thesis, covered the period of 1899-2013.