الفهرس 
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Abstract
This work was conducted on 80 adult albino (40 female and 40 male) rats of Sprague Dawley the average weight of rat before the experiment was ranged from (140-150 g) and age between (17 to19 weeks). The rats were feed on high fat diet by replacing {200 g starch by 200 g of animal fat} for six weeks to induce obesity until reached (200±10 g) were randomly classified into two main groups each group contain 8 subgroup (5 rats each). The first main group classified into normal control group, fed on standard diet only. The other seven subgroups were fed on high fat diet to induced obesity and reclassified into obese control (untreated) and treated rat groups that were orexin (20 mg/kg b.w/i.p), iron (100 g/kg diet), calcium (6 g/kg diet) and zinc (18 g/kg diet), methionine and cysteine (4.5 g/100 g protein diet) and Mixture treated groups. The second main group classified into normal control group, fed on standard diet only. The other seven subgroups were fed on high fat diet and administered aluminum chloride (22 mg/kg b.w) to induced obesity and Alzheimer’s and reclassified at the same first group. The duration of the study was eight weeks. The results of the obese and obese and Alzheimer’s rats groups: revealed that there was a significant decrease in body weight gain, weight gain percent, feed efficiency ratio, body mass index, serum cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, total lipids, atherogenic indexes, serum alanine and aspartate amino transferase (ALT& AST), alkaline phosphatas (ALP) enzymes, direct bilirubin, indirect bilirubin, total bilirubin, creatinine, urea, uric acid ,brain levels of malondialdehyde and B-amyloid but significant increase in serum high density lipoprotein cholesterol iron, zinc, calcium, total protein, brain catalase, glutathione-S- transferase and superoxide dismutase (SOD) among all rats treated group with orexin, calcium, iron, zinc methionine and cysteine and mixture of them in comparing with non-treated positive control female or male rats groups. Histopatholgical results revealed improvement in liver and brain histology in all groups which treated with iron, calcium, zinc, methionine and cysteine) and Mixture. These biochemical changes were accompanied with histopathological alterations in brain tissue. It is concluded that the treatment with minerals could ameliorate most of the evaluated biochemical parameters and improve the induced degenerative histopathological changes.