الفهرس 
Introduction & Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
The liver is one of the most important organs of the human body affects all the systems. It is as a vital organ in the body is primarily responsible for the metabolism of endogenous and exogenous agents. Thioacetamide (TAA) is one of the most widely used chemical in the medicals and industrial field; it is used as an antifungal agent, as an organic solvent, in the manufacture of rubber and motor oils, and in the qualitative analysis of inorganic materials. Previous research studies have reported bad effects of TAA on different body organs and are therefore used to cause liver toxicity and carcinogenesis. Marjoram (Origanum majorana Lamiaceae) is a plant found throughout the world for food uses, marjoram (M) is employed to flavor sausage, meat, salad and soups. Also, marjoram leaves has antioxidant, antihyperglycemic and antili.pidemic effects. Therefore, this study was conducted to study the protective effect of M leaves extract on hepatocellular disorder caused by TAA in male rats. In the present study, male rats weighing 180-200 g were divided into eight groups, each containing 6 rats. At the end of the experimental period (8 wks.), the blood samples were collected from the rats to separate the serum for use in the biochemical analysis. Then, the rats were dissected and the liver was separated, cleaned and weighed. Liver samples were then weighed and homogenized in phosphate puffer solution and then kept at -20 Cº until used in different biochemicals analyzes. Other samples of the liver tissue were kept at -80 Cº until used in the measurement of cell apoptosis. Alos, other samples of the liver tissue were stored in neutral formalin (10%) for histopathological examination. Conclusion: The study concluded that M ethanolic extract has a protective role against hepatic disorders caused by TAA, with noting that the high concentration dose of M extract has a better protective effect than low concentration and its effect is similar to that of silymarin. The continuation of researchs using each of the active ingredients of M leaves and with different concentrations are needed to access the dose to treat various liver diseases