الفهرس 
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Abstract
The skeletal dysplasias are groups of more than 450 inheritable disorders of bone. They frequently present in the neonatal period with disproportionate short stature, radiographic abnormalities, and other organ system abnormalities. The bone age of children indicates their level of biological and structural maturity. The commonest tool used to calculate bone age is by using X-ray of the hand & wrist. Thyroid hormones are important for skeletal growth and important regulators of bone maintenance. Childhood hypothyroidism causes delayed skeletal development, retarded linear growth and impaired bone mineral accrual. The aim of work was assessment of the bone age and the thyroid function in skeletal dysplasia patients followed in Genetic Clinic of Mansoura University Children’s Hospital (MUCH). This study has been conducted on 50 patients. Informed consents was taken from parents of each case. The included patients were classified in to 2 groups: group 1: A: Achondroplasia B: Hypochondroplasia group 2: A: Osteogenesis imperfecta B: Other types of skeletal dysplasia The included patients were subjected to history, clinical examination, bone survey, bone age assessment by Tanner Whitehouse (TW2) Method and laboratory investigations including serum thyroid hormones (TSH, T4 and T3). We concluded that:1.In achondroplasia and hypochondroplasia there was no significant delay in bone age in contrast with osteogenesis imperfecta and other types of skeletal dysplasia where there was a significant delay in bone age 2.There were no significant abnormalities in thyroid function tests in studied groups