الفهرس 
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Abstract
Introduction: Lung cancer, a disease characterized by uncontrolled cell growth in the lungs, has the third most incidence rate and the highest death rate of all cancer types. The research and development of nanotechnology is very active globally. Silver nanoparticles (AgNPs) are proved preferred for tumor controlling as it focuses on the mitochondrial system consequently constraining adenosine triphosphate (ATP) and controlling biological pathways for cell survival. recent investigations have revealed promising outcomes in various lung cancer cell lines Aim of the Work: The present study was conducted to investigate the molecular gene effect of nanomodified silver particles on treatment of lung cancer compared to that of traditional treatment regimens. Research plan: Sixty randomly selected NSCLC patients were assembled in this study. Patients under study were divided into four groups according to the mode of treatment each group included 15 patients. Result: Silver nanoparticles demonstrated significant reduction in the expression of PROM1, EZR, NANOG, BMI1, POU5F1, SOX2, NOTCH1, ABCG2, CD44, CTNNB1, MALAT1, HOTAIR, H19, c-MYC, c-MET, ERCC1, DDR2, KRAS, ANXA2, EGFR, BRCA1, MTOR, RALA, and PIK3CA, and BCL2. AgNPs significantly induced the up-regulation of TP53, BAX, FAS, GAS5, CDKN2A, and PTEN in NSCLC compared to that of systemic chemotherapy. NaHCO3 treatment significantly reduced the expression of BMI1, EZR, SOX2, NANOG, NOTCH1, CTNNB1 and PROM1), lncRNA genes (MALAT1, HOTAIR, and H19, ERCC1, DDR2, ANXA2, EGFR, BRCA1, RALA, and PIK3CA expressions compared to that of systemic chemotherapy. NaHCO3 demonstrated a statistically significant induction of PTEN gene expression in NSCLC compared to that of systemic chemotherapy.