الفهرس 
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Abstract
The current investigation focused on evaluating the impacts of water quality and wastewater pollution on the Eco-physiology of African catfish, C. gariepinus sampled from two different freshwater ecosystems during the period from November 2017 to October 2018. The Damietta branch of River Nile was selected as the control or less polluted ecosystem and El-Serw Drain was selected as more polluted ecosystem because it received enormous amounts of agriculture and domestic wastes from urban surrounding this drain. The obtained results showed that El-Serw Drain was rich in chemical and biological contents as well as elevated levels of electric conductivity. it was clearly that the concentrations of Cu, Pb, Cd, Cr, Zn, Fe, and Co were higher in El-Serw drain water than those in the control water. Also, it was obvious that the heavy metals concentrations in El-Serw sediments. the CAT and GSH values exhibited elevation in fish blood serum from El-Serw drain than those in River Nile fish. This may be related to fish tolerance and acclimation to stress conditions. Also, the decreased levels of MDA in fish blood serum from El-Serw Drain.