الفهرس 
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Abstract
The present thesis is devoted for developing new methods for the analysis of drugs affecting CNS, namely: Levodopa (LVD), carbidopa (CBD), entacapone (ETC), carbamazepine (CMZ), oxcarbazepine (OXZ), eslicarbazepine acetate (ESZ), bromazepam (BMZ), diazepam (DIZ), clonazepam (CNP), imatinib (IMB), gemifloxacin (GMI), nalbuphine (NLP) and naproxen (NAP) either in pure form, in pharmaceutical preparations, in content uniformity testing or in human plasma and urine samples, in dissolution rate testing. The principles of the proposed procedures as well as the experimental parameters and proposal schemes of the reactions were studied, discussed and explained. Furthermore, the data given were statistically analyzed and compared with those obtained by the comparison methods. Different analytical techniques were applied for determination of the studied compounds. Spectrofluorimetry was investigated for determination of ETC in tablets and real human plasma using tween 80 or carboxy methyl cellulose (CMC) as enhancers. A sensitive and specific micellar spectrofluorimetric method was also developed for determination of CNP in tablets using CMC as enhancer. The method was further applied to content uniformity testing and human plasma. Moreover, a micellar HPLC method was developed for determination of LVD, CBD and ETC or LVD and CBD with UV-detection in tablets. As, the method was sensitive enough it was further applied in real human plasma. Additionally, a rapid, simple and highly sensitive micellar HPLC method with UV-detection was developed for determination of OXZ, ESZ and CMZ in pharmaceutical dosage forms. The method was further applied to real human plasma and urine and or dissolution rate testing. Chemometric assisted / spectrophotometric for determination of BMZ, DIZ and CNP in tablets was performed. The method was further applied to content uniformity testing and or human urine and or dissolution rate testing. Finally, extended ratio derivative and partial least squares were developed for the simultaneous analysis of IMB, GMI, NLP and NAP in their co-administered tablets and human urine. The validation criteria of the developed methods were intensively studied. All the results were statistically analyzed and compared with those given by official or comparison methods.