الفهرس 
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Abstract
The current work aimed to detect the effect of serotonin and tryptophan on atherosclerotic vascular disease in rats. 48 rats (200± 10 gm body weight) were divided equally into 6 groups. G1: rats fed on a standard diet. G2: rats fed on a high-fat diet. G 3: rats fed on a high-fat diet and were intranasally given 1 mg/mL of serotonin in 0.1 M citrate buffer, G4: rats fed on a standard diet, and were intranasally given 1 mg/mL of serotonin in 0.1 M citrate buffer. G5: rats fed on a high-fat diet and were given orally with 100 mg L-tryptophan /kg b.w. G6: rats fed on a standard diet and were given orally with 100 mg L-tryptophan /kg b.w. The expirmant extended for 8 weeks. The obtained results recorded a significant improvement in antioxidant activities and lipid profile of rats treated with serotonin or tryptophan even with HFD feeding. The results revealed that administration of serotonin or tryptophan induce a significant up regulation (p˂ 0.05) in 5-HT2A expression and a significant down-regulation in interleukin IL-6 expression in cerebellum tissue. Moreover, administration of serotonin or tryptophan improved the endothelial dysfunction and showed strong brown stained immunoreactivity for serotonin receptor in coronary artery and heart. The results of the present investigation highlight the protective effect of serotonin or tryptophan even in atherosclerotic rats.